Doxepin is a tricyclic antidepressant (TCA) used as a pill to treat major depressive disorder, anxiety disorders, chronic hives, and for short-term help with trouble remaining asleep after going to bed (a form of insomnia). As a cream it is used for short term treatment of itchiness due to atopic dermatitis or lichen simplex.
As of October 2017, doxepin is marketed under many brand names worldwide: Adnor, Anten, Antidoxe, Colian, Dofu, Doneurin, Dospin, Doxal, Doxepini, Doxesom, Doxiderm, Flake, Gilex, Ichderm, Li Ke Ning, Mareen, Noctaderm, Oxpin, Patoderm, Prudoxin, Qualiquan, Quitaxon, Sagalon, Silenor, Sinepin, Sinequan, Sinequan, Sinquan, and Zonalon. It is also marketed as a combination drug with levomenthol under the brand name Doxure.
Following a single very low dose of 6 mg, peak plasma levels of doxepin are 0.854 ng/mL (3.06 nmol/L) at 3 hours without food and 0.951 ng/mL (3.40 nmol/L) at 6 hours with food.
(doxepin HCl) Capsules and Oral Concentrate. Suicidality and Antidepressant Drugs. Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders.
Doxepin is primarily metabolized by CYP2D6 (with CYP1A2 & CYP3A4 as minor pathways). The clinical significance of this interaction with doxepin has not been systematically evaluated. The extent of interaction depends on the variability of effect on CYP2D6. Inhibitors or substrates of CYP2D6 (i.e., quinidine, selective serotonin reuptake inhibitors ) may increase the plasma concentration of doxepin when administered concomitantly.
This is especially important in patients who may use alcohol excessively.
This medication is used to treat mental/mood problems such as depression and anxiety. It may help improve mood and feelings of well-being, relieve anxiety and tension, help you sleep better, and increase your energy level. This medication belongs to a class of medications called tricyclic antidepressants.
Do not double the dose to catch up. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule. If you miss a dose, take it as soon as you remember.
Follow your doctor's instructions carefully. To reduce your risk of side effects (such as drowsiness, dry mouth, dizziness ), your doctor may direct you to start this medication at a low dose and gradually increase your dose.
Things to remember when you fill your prescription.
Who should not take Doxepin HCL Capsule?
Before using doxepin, l your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems ( heart failure, slow heartbeat, QT prolongation in the EKG ), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).
Doxepin is used to treat depression and anxiety. Doxepin is in a class of medications called tricyclic antidepressants. It works by increasing the amounts of certain natural substances in the brain that are needed for mental balance.
If the victim has collapsed or is not breathing, call local emergency services at 911. In case of overdose, call your local poison control center at.
Unless your doctor ls you otherwise, continue your normal diet.
Your doctor will probably want to decrease your dose gradually. Continue to take doxepin even if you feel well. It may take several weeks or longer for you to feel the full effect of doxepin. Do not stop taking doxepin without talking to your doctor.
Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.
Easy to read patient leaflet for Doxepin Tablets. Includes indications, proper use, special instructions, precautions, and possible side effects.
Anxiety Xanax, Lexapro, Cymbalta, atenolol, alprazolam, lorazepam, More.
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Call your doctor for medical advice about side effects. If you have questions about side effects, call your doctor. These are not all of the side effects that may occur.
Other brands: Silenor, Sinequan Availability Prescription only.
However, many people have no side effects or only have minor side effects. All drugs may cause side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:.
Side Effects (complete list).
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