I'll be interested to hear if patients find Intermezzo more effective than low dose generic zolpidem for getting back to sleep after early awakening, but I suspect that a 2.5 mg or 5 mg dose orally will be pretty similar in efficacy, and much easier on the pocketbook. Please leave a comment if you have tried.
Patients have been taking a half dose of a 5 or 10 mg zolpidem for this purpose for some time, although it is not an FDA approved indication. The effect of zolpidem taken orally in most people is only about 3-4 hours anyway, although in some people the effect can be longer. Does the sublingual route of administration make much difference? It is possible that if the drug is absorbed directly into the bloodstream through the oral mucosa that the serum levels are achieved more quickly than with oral ingestion, and if so in theory the medication may be more quickly cleared from the bloodstream and the hypnotic effect may last slightly less time.
I’ll be interested to hear if patients find Intermezzo more effective than low dose generic zolpidem for getting back to sleep after early awakening, but I suspect that a 2.5 mg or 5 mg dose orally will be pretty similar in efficacy, and much easier on the pocketbook.
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